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Objective@#To investigate the clinical effect of knee arthroscopy combined with celecoxib in the treatment of elderly patients with knee osteoarthritis.@*Methods@#According to the random table method, 62 elderly patients with knee osteoarthritis admitted to the Third People's Hospital of Zhuji from October 2016 to October 2018 were divided into control group (31 cases) and observation group (31 cases) according to the digital table.The control group was treated with knee arthroscopic debridement, while the observation group was orally given celecoxib on the basis of the control group.Both two groups were treated for 12 weeks.The curative effect of the two groups was compared, and the changes of WOMAC scale score, knee joint active flexion and extension and inflammatory factors before and after treatment were compared.@*Results@#The excellent and good rate of the observation group (83.88%) was higher than that of the control group (51.62%) (χ2=7.381, P<0.05). After treatment, the scores of stiffness[(3.56±0.38)points], difficulty in daily activities[(27.38±7.19)points]and pain[(7.94±2.45)points] in the observation group were lower than those in the control group[(5.81±0.76)points, (38.98±5.42)points and (11.36±1.87)points](t=10.182, 14.743, 6.178, all P<0.05). After treatment, the knee joint active flexion and extension in the observation group[(91.24±7.86)°] was higher than that in the control group[(83.42±7.39)°](t=4.036, P<0.05). After treatment, the serum levels of IL-1beta[(16.58±4.25)ng/L], TNF-α[(183.25±24.15)ng/L]and IL-6[(9.98±2.43) ng/L] in the observation group were lower than those in the control group[(26.31±5.47)ng/L, (219.82±29.96)ng/L and (14.52±4.35)ng/L](t=7.821, 5.291, 5.073, all P<0.05).@*Conclusion@#Knee arthroscopy combined with celecoxib has good clinical effect on elderly patients with knee osteoarthritis.It can improve knee function, alleviate inflammation and improve active knee flexion and extension.
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Objective To investigate the clinical effect of knee arthroscopy combined with celecoxib in the treatment of elderly patients with knee osteoarthritis.Methods According to the random table method,62 elderly patients with knee osteoarthritis admitted to the Third People's Hospital of Zhuji from October 2016 to October 2018 were divided into control group (31 cases) and observation group (31 cases) according to the digital table.The control group was treated with knee arthroscopic debridement ,while the observation group was orally given celecoxib on the basis of the control group.Both two groups were treated for 12 weeks.The curative effect of the two groups was compared,and the changes of WOMAC scale score,knee joint active flexion and extension and inflammatory factors before and after treatment were compared.Results The excellent and good rate of the observation group (83.88％) was higher than that of the control group (51.62％) (χ2 =7.381,P<0.05).After treatment,the scores of stiffness[(3.56 ±0.38)points], difficulty in daily activities[(27.38 ±7.19)points]and pain[(7.94 ±2.45)points] in the observation group were lower than those in the control group [(5.81 ±0.76)points,(38.98 ±5.42)points and (11.36 ±1.87)points](t=10.182,14.743,6.178,all P<0.05).After treatment,the knee joint active flexion and extension in the observation group[(91.24 ±7.86)°] was higher than that in the control group [(83.42 ±7.39)°](t=4.036,P<0.05).After treatment,the serum levels of IL -1beta[(16.58 ±4.25) ng/L],TNF-α[(183.25 ±24.15) ng/L] and IL -6 [(9.98 ±2.43) ng/L] in the observation group were lower than those in the control group [(26.31 ±5.47)ng/L, (219.82 ±29.96)ng/L and (14.52 ±4.35)ng/L](t =7.821,5.291,5.073,all P <0.05).Conclusion Knee arthroscopy combined with celecoxib has good clinical effect on elderly patients with knee osteoarthritis .It can improve knee function,alleviate inflammation and improve active knee flexion and extension .
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Objective To explore the clinical efficacy and safety of ropivacaine for combined spinal-epidural anesthesia(CSE).Methods 40 patients,who intended to undergo elective lower limb or perineum surgery,were randomly divided into two groups,each with 20 cases,ropivacaine were used in treatment group,while bupivacaine in control group the differences of feeling,motor block and recovery time,as well as their side effect in the two groups were compared.Results The maximum of spread time of anesthesia and the recovery time,and side effect in treatment group were similar to those in control group.The onset time of motor block and the peak time of motor block were longer in treatment group than that in control group,the maximum modified Bromage scale in treatment group was lower than that in control group(P
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0.05),but decrease of BP in groupⅠandⅡhad conspicuous difference compared with groupⅢ(P